diff --git a/.changeset/card-compact-layout.md b/.changeset/card-compact-layout.md
new file mode 100644
index 00000000000..c676741df9a
--- /dev/null
+++ b/.changeset/card-compact-layout.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': minor
+---
+
+Card: Add `layout="compact"` prop for a compact card layout with tighter spacing, no icon background, and smaller title
diff --git a/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-dark-colorblind-linux.png b/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-dark-colorblind-linux.png
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diff --git a/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-light-high-contrast-linux.png b/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-light-high-contrast-linux.png
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diff --git a/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-light-tritanopia-linux.png b/.playwright/snapshots/components/Card.test.ts-snapshots/Card-Compact-light-tritanopia-linux.png
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diff --git a/e2e/components/Card.test.ts b/e2e/components/Card.test.ts
index 8c4e77acfde..1b583566aac 100644
--- a/e2e/components/Card.test.ts
+++ b/e2e/components/Card.test.ts
@@ -56,4 +56,22 @@ test.describe('Card', () => {
       })
     }
   })
+
+  test.describe('Compact', () => {
+    for (const theme of themes) {
+      test.describe(theme, () => {
+        test('default @vrt', async ({page}) => {
+          await visit(page, {
+            id: 'experimental-components-card-features--compact',
+            globals: {
+              colorScheme: theme,
+            },
+          })
+
+          // Default state
+          expect(await page.screenshot()).toMatchSnapshot(`Card.Compact.${theme}.png`)
+        })
+      })
+    }
+  })
 })
diff --git a/packages/react/src/Card/Card.features.stories.tsx b/packages/react/src/Card/Card.features.stories.tsx
index a8ef6d5a1e3..dc6b2f286d2 100644
--- a/packages/react/src/Card/Card.features.stories.tsx
+++ b/packages/react/src/Card/Card.features.stories.tsx
@@ -28,6 +28,22 @@ export const WithImage = () => {
   )
 }
 
+export const Compact = () => {
+  return (
+    <Card layout="compact">
+      <Card.Icon icon={RepoIcon} />
+      <Card.Heading>primer/react</Card.Heading>
+      <Card.Description>
+        The compact layout uses tighter spacing, an icon without a background container, and a smaller title.
+      </Card.Description>
+      <Card.Metadata>
+        <StarIcon size={16} />
+        1.2k stars
+      </Card.Metadata>
+    </Card>
+  )
+}
+
 export const WithMetadata = () => {
   return (
     <Card>
diff --git a/packages/react/src/Card/Card.module.css b/packages/react/src/Card/Card.module.css
index 53360e1e55d..e0e463e81d9 100644
--- a/packages/react/src/Card/Card.module.css
+++ b/packages/react/src/Card/Card.module.css
@@ -29,12 +29,28 @@
   &[data-padding='none'] {
     padding: 0;
   }
+
+  &[data-layout='compact'] {
+    display: flex;
+    align-items: flex-start;
+    gap: var(--stack-gap-condensed);
+  }
+
+  &[data-layout='compact'][data-padding='normal'] {
+    /* stylelint-disable-next-line primer/spacing */
+    padding: var(--stack-padding-normal);
+  }
 }
 
 .CardHeader {
   display: block;
   width: 100%;
   height: auto;
+
+  .Card:where([data-layout='compact']) & {
+    flex: 0 0 auto;
+    width: auto;
+  }
 }
 
 .CardHeaderEdgeToEdge {
@@ -55,17 +71,25 @@
 .CardIcon {
   display: flex;
   align-items: center;
-  justify-content: center;
-  width: var(--base-size-32);
-  height: var(--base-size-32);
-  border-radius: var(--borderRadius-medium);
-  background-color: var(--bgColor-muted);
+  justify-content: flex-start;
   color: var(--fgColor-muted);
+
+  .Card:where([data-layout='default']) & {
+    justify-content: center;
+    width: var(--base-size-32);
+    height: var(--base-size-32);
+    border-radius: var(--borderRadius-medium);
+    background-color: var(--bgColor-muted);
+  }
 }
 
 .CardBody {
   display: grid;
   gap: var(--stack-gap-normal);
+
+  .Card:where([data-layout='compact']) & {
+    flex: 1 1 auto;
+  }
 }
 
 .CardContent {
@@ -77,6 +101,12 @@
   font: var(--text-title-shorthand-small);
   color: var(--fgColor-default);
   margin: 0;
+
+  .Card:where([data-layout='compact']) & {
+    position: relative;
+    top: calc(-1 * var(--base-size-4));
+    font-size: var(--text-body-size-medium);
+  }
 }
 
 .CardDescription {
diff --git a/packages/react/src/Card/Card.stories.tsx b/packages/react/src/Card/Card.stories.tsx
index 3f0f9d30e54..eef867be2a4 100644
--- a/packages/react/src/Card/Card.stories.tsx
+++ b/packages/react/src/Card/Card.stories.tsx
@@ -33,12 +33,13 @@ export const Default = () => {
 type PlaygroundArgs = {
   showIcon: boolean
   showMetadata: boolean
+  layout: 'default' | 'compact'
   padding: 'none' | 'condensed' | 'normal'
   borderRadius: 'medium' | 'large'
 }
 
-export const Playground: StoryFn<PlaygroundArgs> = ({showIcon, showMetadata, padding, borderRadius}) => (
-  <Card padding={padding} borderRadius={borderRadius}>
+export const Playground: StoryFn<PlaygroundArgs> = ({showIcon, showMetadata, layout, padding, borderRadius}) => (
+  <Card layout={layout} padding={padding} borderRadius={borderRadius}>
     {showIcon && <Card.Icon icon={RocketIcon} />}
     <Card.Heading>Playground Card</Card.Heading>
     <Card.Description>Experiment with the Card component and its subcomponents.</Card.Description>
@@ -49,6 +50,7 @@ export const Playground: StoryFn<PlaygroundArgs> = ({showIcon, showMetadata, pad
 Playground.args = {
   showIcon: true,
   showMetadata: true,
+  layout: 'default',
   padding: 'normal',
   borderRadius: 'large',
 }
@@ -62,6 +64,11 @@ Playground.argTypes = {
     control: {type: 'boolean'},
     description: 'Show or hide the Card.Metadata subcomponent',
   },
+  layout: {
+    control: {type: 'radio'},
+    options: ['default', 'compact'],
+    description: 'Controls the layout of the Card',
+  },
   padding: {
     control: {type: 'radio'},
     options: ['none', 'condensed', 'normal'],
diff --git a/packages/react/src/Card/Card.test.tsx b/packages/react/src/Card/Card.test.tsx
index c20efab9ca6..aeab542fe61 100644
--- a/packages/react/src/Card/Card.test.tsx
+++ b/packages/react/src/Card/Card.test.tsx
@@ -277,4 +277,32 @@ describe('Card', () => {
     )
     expect(container.firstChild).not.toHaveAttribute('as')
   })
+
+  it('should set data-layout to default by default', () => {
+    const {container} = render(
+      <Card>
+        <Card.Heading>Default Variant</Card.Heading>
+      </Card>,
+    )
+    expect(container.firstChild).toHaveAttribute('data-layout', 'default')
+  })
+
+  it('should set data-layout to compact when layout="compact"', () => {
+    const {container} = render(
+      <Card layout="compact">
+        <Card.Icon icon={TestIcon} />
+        <Card.Heading>Compact Card</Card.Heading>
+      </Card>,
+    )
+    expect(container.firstChild).toHaveAttribute('data-layout', 'compact')
+  })
+
+  it('should set data-layout on custom content cards', () => {
+    const {container} = render(
+      <Card layout="compact">
+        <p>Custom</p>
+      </Card>,
+    )
+    expect(container.firstChild).toHaveAttribute('data-layout', 'compact')
+  })
 })
diff --git a/packages/react/src/Card/Card.tsx b/packages/react/src/Card/Card.tsx
index dec74a45f0b..46f79f41727 100644
--- a/packages/react/src/Card/Card.tsx
+++ b/packages/react/src/Card/Card.tsx
@@ -22,6 +22,13 @@ export type CardProps<As extends CardAs = 'div'> = PolymorphicProps<
     /** Border radius. @default 'large' */
     borderRadius?: 'medium' | 'large'
 
+    /**
+     * Layout of the card. `compact` uses tighter spacing, removes the icon
+     * background container, and renders a smaller title.
+     * @default 'default'
+     */
+    layout?: 'default' | 'compact'
+
     /**
      * Card contents. Provide either `Card.*` subcomponents (e.g. `Card.Heading`,
      * `Card.Description`, `Card.Metadata`) or custom content.
@@ -93,6 +100,7 @@ function CardComponent<As extends CardAs>(
     className,
     padding = 'normal',
     borderRadius = 'large',
+    layout = 'default',
     as = 'div',
     ...rest
   } = props as CardProps<CardAs>
@@ -149,6 +157,7 @@ function CardComponent<As extends CardAs>(
           data-component="Card"
           data-padding={padding}
           data-border-radius={borderRadius}
+          data-layout={layout}
           {...rest}
         >
           {children}
@@ -165,6 +174,7 @@ function CardComponent<As extends CardAs>(
         data-component="Card"
         data-padding={padding}
         data-border-radius={borderRadius}
+        data-layout={layout}
         {...rest}
       >
         {(image || icon) && (